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uk rabbit anti human ezh2  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc uk rabbit anti human ezh2
    Figure 2 Genetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Amplification of BMI1 and <t>EZH2</t> was observed by fluorescence in situ hybridization in recurrent tumor tissues, with intensive expression of proteins detected by immunohistochemistry simultaneously. (A) BMI1 signals in primary tumors. (B) BMI1 signals in recurrent tumors. (C) EZH2 signals in primary tumors. (D) EZH2 signals in recurrent tumors. Note: Bars represent 25 µm.
    Uk Rabbit Anti Human Ezh2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 929 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/uk+rabbit+anti+human+ezh2/10__2147_slash_ott__s67570-150-68-73?v=Cell+Signaling+Technology+Inc
    Average 96 stars, based on 929 article reviews
    uk rabbit anti human ezh2 - by Bioz Stars, 2026-08
    96/100 stars

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    1) Product Images from "Tumor heterogeneity in the recurrence of epithelial ovarian cancer demonstrated by polycomb group proteins"

    Article Title: Tumor heterogeneity in the recurrence of epithelial ovarian cancer demonstrated by polycomb group proteins

    Journal: OncoTargets and Therapy

    doi: 10.2147/ott.s67570

    Figure 2 Genetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Amplification of BMI1 and EZH2 was observed by fluorescence in situ hybridization in recurrent tumor tissues, with intensive expression of proteins detected by immunohistochemistry simultaneously. (A) BMI1 signals in primary tumors. (B) BMI1 signals in recurrent tumors. (C) EZH2 signals in primary tumors. (D) EZH2 signals in recurrent tumors. Note: Bars represent 25 µm.
    Figure Legend Snippet: Figure 2 Genetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Amplification of BMI1 and EZH2 was observed by fluorescence in situ hybridization in recurrent tumor tissues, with intensive expression of proteins detected by immunohistochemistry simultaneously. (A) BMI1 signals in primary tumors. (B) BMI1 signals in recurrent tumors. (C) EZH2 signals in primary tumors. (D) EZH2 signals in recurrent tumors. Note: Bars represent 25 µm.

    Techniques Used: Expressing, Amplification, Fluorescence, In Situ Hybridization, Immunohistochemistry

    Figure 3 Epigenetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Notes: (A) miRNA microarray expression profiling of six pairs of primary and recurrent ovarian tumor tissues: heat map shows eight downregulated (fold change .2) miRNAs in recurrent tumors. (B) Luciferase reporter assay: (B1) miR-4261 and miR-298 significantly suppressed the luciferase activity of ZNF207 and ILF3 (P=0.001, P=0.008); (B2) ZNF207 and ILF3 significantly promoted the luciferase activity of EZH2-promoter reporter plasmid (P=0.000, P=0.000). (C) Transfection of miR-4261 (C1 and C3) and miR-298 (C2 and C4) mimics into ovarian cancer cells, A2780 and OVCAR8, confirmed by real-time polymerase chain reaction and fluorescence. (D) Expression of ZNF207, ILF3, and EZH2 in ovarian cancer cells after miR-4261 and miR-298 upregulation: (D1, D2, and D4) a significant reduction of ZNF207 and ILF3 at mRNA and protein levels was observed (for ZNF207, P=0.001 both; for ILF3, P=0.000, P=0.001); (D3 and D4) EZH2 expression was only concomitantly reduced significantly by miR-298 overexpression (P=0.001 both). Abbreviation: miRNA, microRNA.
    Figure Legend Snippet: Figure 3 Epigenetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Notes: (A) miRNA microarray expression profiling of six pairs of primary and recurrent ovarian tumor tissues: heat map shows eight downregulated (fold change .2) miRNAs in recurrent tumors. (B) Luciferase reporter assay: (B1) miR-4261 and miR-298 significantly suppressed the luciferase activity of ZNF207 and ILF3 (P=0.001, P=0.008); (B2) ZNF207 and ILF3 significantly promoted the luciferase activity of EZH2-promoter reporter plasmid (P=0.000, P=0.000). (C) Transfection of miR-4261 (C1 and C3) and miR-298 (C2 and C4) mimics into ovarian cancer cells, A2780 and OVCAR8, confirmed by real-time polymerase chain reaction and fluorescence. (D) Expression of ZNF207, ILF3, and EZH2 in ovarian cancer cells after miR-4261 and miR-298 upregulation: (D1, D2, and D4) a significant reduction of ZNF207 and ILF3 at mRNA and protein levels was observed (for ZNF207, P=0.001 both; for ILF3, P=0.000, P=0.001); (D3 and D4) EZH2 expression was only concomitantly reduced significantly by miR-298 overexpression (P=0.001 both). Abbreviation: miRNA, microRNA.

    Techniques Used: Expressing, Microarray, Luciferase, Reporter Assay, Activity Assay, Plasmid Preparation, Transfection, Real-time Polymerase Chain Reaction, Fluorescence, Over Expression



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    uk rabbit anti human ezh2  (Cell Signaling Technology Inc)
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    Cell Signaling Technology Inc uk rabbit anti human ezh2
    Figure 2 Genetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Amplification of BMI1 and <t>EZH2</t> was observed by fluorescence in situ hybridization in recurrent tumor tissues, with intensive expression of proteins detected by immunohistochemistry simultaneously. (A) BMI1 signals in primary tumors. (B) BMI1 signals in recurrent tumors. (C) EZH2 signals in primary tumors. (D) EZH2 signals in recurrent tumors. Note: Bars represent 25 µm.
    Uk Rabbit Anti Human Ezh2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/uk+rabbit+anti+human+ezh2/10__2147_slash_ott__s67570-150-68-73?v=Cell+Signaling+Technology+Inc
    Average 96 stars, based on 1 article reviews
    uk rabbit anti human ezh2 - by Bioz Stars, 2026-08
    96/100 stars
    		  Buy from Supplier

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    Figure 2 Genetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Amplification of BMI1 and EZH2 was observed by fluorescence in situ hybridization in recurrent tumor tissues, with intensive expression of proteins detected by immunohistochemistry simultaneously. (A) BMI1 signals in primary tumors. (B) BMI1 signals in recurrent tumors. (C) EZH2 signals in primary tumors. (D) EZH2 signals in recurrent tumors. Note: Bars represent 25 µm.

    Journal: OncoTargets and Therapy

    Article Title: Tumor heterogeneity in the recurrence of epithelial ovarian cancer demonstrated by polycomb group proteins

    doi: 10.2147/ott.s67570

    Figure Lengend Snippet: Figure 2 Genetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Amplification of BMI1 and EZH2 was observed by fluorescence in situ hybridization in recurrent tumor tissues, with intensive expression of proteins detected by immunohistochemistry simultaneously. (A) BMI1 signals in primary tumors. (B) BMI1 signals in recurrent tumors. (C) EZH2 signals in primary tumors. (D) EZH2 signals in recurrent tumors. Note: Bars represent 25 µm.

    Article Snippet: Mouse anti-human BMi1 1:200 abcam, cambridge, UK rabbit anti-human ring1 1:250 abcam, cambridge, UK goat anti-human ring2 1:100 abcam, cambridge, UK rabbit anti-human PhF1 1:50 abcam, cambridge, UK goat anti-human Mel18 1:500 santa cruz Biotechnology, ca, Usa goat anti-human Phc1 1:200 santa cruz Biotechnology, ca, Usa goat anti-human cBX2 1:200 santa cruz Biotechnology, ca, Usa rabbit anti-human cBX4 1:200 abcam, cambridge, UK Mouse anti-human rYBP 1:600 abcam, cambridge, UK rabbit anti-human eZh2 1:200 cell signaling, Danvers, Ma, Usa rabbit anti-human eeD 1:200 abcam, cambridge, UK Mouse anti-human sUZ12 1:500 abcam, cambridge, UK MaxVisionTM hrP-Polymer goat anti-mouse/rabbit ihc Kit \ Maixin Biological Technology Development company, Fuzhou, People’s republic of china MaxVisionTM hrP-Polymer rabbit anti-goat ihc Kit \ Maixin Biological Technology Development company, Fuzhou, People’s republic of china Abbreviations: hrP, horseradish peroxidase; ihc, immunohistochemistry.

    Techniques: Expressing, Amplification, Fluorescence, In Situ Hybridization, Immunohistochemistry

    Figure 3 Epigenetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Notes: (A) miRNA microarray expression profiling of six pairs of primary and recurrent ovarian tumor tissues: heat map shows eight downregulated (fold change .2) miRNAs in recurrent tumors. (B) Luciferase reporter assay: (B1) miR-4261 and miR-298 significantly suppressed the luciferase activity of ZNF207 and ILF3 (P=0.001, P=0.008); (B2) ZNF207 and ILF3 significantly promoted the luciferase activity of EZH2-promoter reporter plasmid (P=0.000, P=0.000). (C) Transfection of miR-4261 (C1 and C3) and miR-298 (C2 and C4) mimics into ovarian cancer cells, A2780 and OVCAR8, confirmed by real-time polymerase chain reaction and fluorescence. (D) Expression of ZNF207, ILF3, and EZH2 in ovarian cancer cells after miR-4261 and miR-298 upregulation: (D1, D2, and D4) a significant reduction of ZNF207 and ILF3 at mRNA and protein levels was observed (for ZNF207, P=0.001 both; for ILF3, P=0.000, P=0.001); (D3 and D4) EZH2 expression was only concomitantly reduced significantly by miR-298 overexpression (P=0.001 both). Abbreviation: miRNA, microRNA.

    Journal: OncoTargets and Therapy

    Article Title: Tumor heterogeneity in the recurrence of epithelial ovarian cancer demonstrated by polycomb group proteins

    doi: 10.2147/ott.s67570

    Figure Lengend Snippet: Figure 3 Epigenetic heterogeneity underlying the heterogeneous expression of polycomb group proteins. Notes: (A) miRNA microarray expression profiling of six pairs of primary and recurrent ovarian tumor tissues: heat map shows eight downregulated (fold change .2) miRNAs in recurrent tumors. (B) Luciferase reporter assay: (B1) miR-4261 and miR-298 significantly suppressed the luciferase activity of ZNF207 and ILF3 (P=0.001, P=0.008); (B2) ZNF207 and ILF3 significantly promoted the luciferase activity of EZH2-promoter reporter plasmid (P=0.000, P=0.000). (C) Transfection of miR-4261 (C1 and C3) and miR-298 (C2 and C4) mimics into ovarian cancer cells, A2780 and OVCAR8, confirmed by real-time polymerase chain reaction and fluorescence. (D) Expression of ZNF207, ILF3, and EZH2 in ovarian cancer cells after miR-4261 and miR-298 upregulation: (D1, D2, and D4) a significant reduction of ZNF207 and ILF3 at mRNA and protein levels was observed (for ZNF207, P=0.001 both; for ILF3, P=0.000, P=0.001); (D3 and D4) EZH2 expression was only concomitantly reduced significantly by miR-298 overexpression (P=0.001 both). Abbreviation: miRNA, microRNA.

    Article Snippet: Mouse anti-human BMi1 1:200 abcam, cambridge, UK rabbit anti-human ring1 1:250 abcam, cambridge, UK goat anti-human ring2 1:100 abcam, cambridge, UK rabbit anti-human PhF1 1:50 abcam, cambridge, UK goat anti-human Mel18 1:500 santa cruz Biotechnology, ca, Usa goat anti-human Phc1 1:200 santa cruz Biotechnology, ca, Usa goat anti-human cBX2 1:200 santa cruz Biotechnology, ca, Usa rabbit anti-human cBX4 1:200 abcam, cambridge, UK Mouse anti-human rYBP 1:600 abcam, cambridge, UK rabbit anti-human eZh2 1:200 cell signaling, Danvers, Ma, Usa rabbit anti-human eeD 1:200 abcam, cambridge, UK Mouse anti-human sUZ12 1:500 abcam, cambridge, UK MaxVisionTM hrP-Polymer goat anti-mouse/rabbit ihc Kit \ Maixin Biological Technology Development company, Fuzhou, People’s republic of china MaxVisionTM hrP-Polymer rabbit anti-goat ihc Kit \ Maixin Biological Technology Development company, Fuzhou, People’s republic of china Abbreviations: hrP, horseradish peroxidase; ihc, immunohistochemistry.

    Techniques: Expressing, Microarray, Luciferase, Reporter Assay, Activity Assay, Plasmid Preparation, Transfection, Real-time Polymerase Chain Reaction, Fluorescence, Over Expression